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2 edition of Mechanisms of CD40 signalling and apoptosis in carcinoma cells found in the catalog.

Mechanisms of CD40 signalling and apoptosis in carcinoma cells

Clare Charlotte Davies

Mechanisms of CD40 signalling and apoptosis in carcinoma cells

by Clare Charlotte Davies

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  • 24 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (PhD) - University of Birmingham, School of Medicine, Cancer Research UK Institute for Cancer Studies.

Statementby Clare Charlotte Davies.
The Physical Object
Pagination223 p. :
Number of Pages223
ID Numbers
Open LibraryOL16029037M

The emergence of immune checkpoint blockade therapies over the last decade has transformed cancer treatment in a wide range of tumor types. Unprecedented and durable clinical responses in difficult-to-treat cancer histologies have been observed. However, despite these promising long-term responses, the majority of patients fail to respond to immune checkpoint blockade, demonstrating primary Cited by: CD40 is a TNF receptor superfamily member that provides activation signals in antigen-presenting cells such as B cells, macrophages, and dendritic cells. Multimerization of CD40 by its ligand initiates signaling by recruiting TNF receptor-associated factors (TRAFs) to the CD40 cytoplasmic domain. Recombinant human TRAF proteins overexpressed in insect cells were biochemically characterized and Cited by:

$\begingroup$ If cells with non-functioning apoptosis mechanisms can be detected by some type of test this would indicate a possible tumor as tumor cells don't have functioning apoptosis mechanisms. (at least that's what somebody else said on this exchange) $\endgroup$ – user Nov 14 '14 at The Cd40 Signaling Pathway complements our catalog of research reagents including antibodies and ELISA kits against CD40, CD40LG, NOD2, TNF, CTLA4. Cd40 Signaling Pathway Bioinformatics Tool Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Aromatase inhibitors (AIs), which block the conversion of androgens to estrogens, are used for hormone-dependent breast cancer treatment. Exemestane, a steroidal that belongs to the third-generation of AIs, is a mechanism-based inhibitor that binds covalently and irreversibly, inactivating and destabilizing aromatase. Since the biological effects of exemestane in breast cancer cells are not.

Sigma offers several small molecules that inhibit a cell’s initiation of or progression through the apoptosis process. This set of compounds includes inhibitors of c-Myc, Bax, p53, tBid, and BCL that mediate apoptosis as well as caspase inhibitors and other enzymes involved in the apoptotic pathways. Apoptosis inhibitors are important research tools when investigating the cellular mechanisms. Cells were then filtered through a 40 μm nylon mesh and centrifuged at xg for 10 min. To lyse red blood cells, the pellet was resuspended in 1 mL of ACK lysing buffer (Lonza) and incubated for 2 min on ice. Cells were then washed in PBS and resuspended in Cited by: 1. Signal regulatory protein (SIRP)α, also known as SHPS-1 or SIRPA, is a transmembrane protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is predominantly expressed in neurons, dendritic cells and macrophages. CD47, a widely expressed transmembrane protein, is a ligand for SIRPα, with the two proteins constituting a cell–cell Cited by:


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Mechanisms of CD40 signalling and apoptosis in carcinoma cells by Clare Charlotte Davies Download PDF EPUB FB2

SyntaxTextGen not [email protected]{osti_, pdf = {p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells}, author = {Huang, Shi-Wei and Wu, Chun-Ying and Wang, Yen-Ting and Kao, Jun-Kai and Department of Pediatrics, Children's Hospital, Changhua Christian Hospital, Changhua, Taiwan and Lin, Chi-Chen and Chang, Chia-Che and Mu.

Effects of CD27 and CD40 ligation on Download pdf apoptosis of Ramos cells that express dominant-negative p53 protein. Stable transfected Ramos cells (1 × 10 5 /well) with p53DN gene or vector alone were co-cultured with mitomycin C-treated transfected cells (2 × 10 4 /well) in the presence of control Ab or anti-IgM Ab (10 μg/ml).The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest ebook cell signaling in innate and ebook immunity.

It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CDCited by: